{"rowid": 56, "title": "[\"High-grade astrocytoma with ventricular invasion in a dog\"]", "DOI": "10.1136/vetreccr-2019-000958", "URL": "http://dx.doi.org/10.1136/vetreccr-2019-000958", "created": "2019-12-03T10:42:48Z", "subject": "[\"General Veterinary\"]", "references-count": "22", "is-referenced-by-count": "0", "ISSN": "[\"2052-6121\"]", "container-title": "Veterinary Record Case Reports", "abstract": "<jats:p>A 13-year-old female German Shepherd dog was euthanised and submitted to necropsy after a 7-month history of prolonged recumbency and vocalisation. Gross anatomical changes consisted of a well-demarcated, 3.5\u00d71.5\u2009cm, soft red mass that effaced the right lateral ventricle and compressed the adjacent neuroparenchyma. Histologically, elongate neoplastic cells with astrocytic morphology were arranged in short bundles and streams supported by a neuropil-like stroma. Neoplastic cells were immunopositive for glial fibrillar acidic protein (GFAP) and oligodendrocyte transcription factor 2 (Olig2), and immunonegative for e-cadherin and pancytokeratin. Histological and immunohistochemical features were consistent with a high-grade astrocytoma with ventricular invasion, a rare feature of astrocytic tumours in dogs.</jats:p>", "author_number": "5", "orcids": "[\"http://orcid.org/0000-0002-7128-8756\"]", "names": "[\"Rayane Chitolina Pupin\", \"Daniel R Rissi\", \"Danilo Carloto Gomes\", \"Amanda Gimelli\", \"Mariana Isa Poci Palumbo\"]", "award_numbers": "[\"\"]", "funder_names": "[\"\"]", "funder_dois": "[\"\"]"}