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Link rowid title DOI URL created subject references-count is-referenced-by-count ISSN container-title ▼ abstract author_number orcids names award_numbers funder_names funder_dois
17 ["Vitamin D and its pathway genes in myopia: systematic review and meta-analysis"] 10.1136/bjophthalmol-2018-312159 http://dx.doi.org/10.1136/bjophthalmol-2018-312159 2018-07-17T16:26:52Z ["Ophthalmology", "Sensory Systems", "Cellular and Molecular Neuroscience"] 56 8 ["0007-1161", "1468-2079"] British Journal of Ophthalmology <jats:sec><jats:title>Objective</jats:title><jats:p>To conduct a systematic review and meta-analysis of the association of blood vitamin D (25-hydroxyvitamin D, 25(OH)D) concentration and vitamin D pathway genes with myopia.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We searched the MEDLINE and EMBASE databases for studies published up to 29 January 2018. Cross-sectional or cohort studies which evaluated the blood 25(OH)D concentration, blood 25(OH)D3 concentration or vitamin D pathway genes, in relation to risk of myopia or refractive errors were included. Standard mean difference (SMD) of blood 25(OH)D concentrations between the myopia and non-myopia groups was calculated. The associations of blood 25(OH)D concentrations and polymorphisms in vitamin D pathway genes with myopia using summary ORs were evaluated.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We summarised seven studies involving 25 008 individuals in the meta-analysis. The myopia group had lower 25(OH)D concentration than the non-myopia group (SMD=−0.27 nmol/L, p=0.001). In the full analysis, the risk of myopia was inversely associated with blood 25(OH)D concentration after adjusting for sunlight exposure or time spent outdoors (adjusted odds ratio (AOR)=0.92 per 10 nmol/L, p&lt;0.0001). However, the association was not statistically significant for the &lt;18 years subgroup (AOR=0.91 per 10 nmol/L, p=0.13) and was significant only for 25(OH)D3 (likely to be mainly sunlight derived), but not total 25(OH)D (AOR=0.93 per 10 nmol/L, p=0.00007; AOR=0.91 per 10 nmol/L, p=0.15). We analysed four single nucleotide polymorphisms in the VDR gene from two studies; there was no significant association with myopia.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Lower 25(OH)D is associated with increased risk of myopia; the lack of a genetic association suggests that 25(OH)D level may be acting as a proxy for time outdoors.</jats:p></jats:sec> 9 ["http://orcid.org/0000-0001-8352-6363", "http://orcid.org/0000-0003-0994-6196", "http://orcid.org/0000-0001-7914-4709", "http://orcid.org/0000-0003-2736-3541", "http://orcid.org/0000-0002-2156-1486"] ["Shu Min Tang", "Tiffany Lau", "Shi Song Rong", "Seyhan Yazar", "Li Jia Chen", "David A Mackey", "Robyn M Lucas", "Chi Pui Pang", "Jason C Yam"] ["14111515 (JCSY)"] ["General Research Fund (GRF), Research Grants Council, Hong Kong", "UBS Optimus Foundation Grant", "Direct Grants of the Chinese University of Hong Kong"] [[""], [""], [""]]
53 ["Diagnostic value of blood variables following attenuation of congenital extrahepatic portosystemic shunt in dogs"] 10.1136/vr.105296 http://dx.doi.org/10.1136/vr.105296 2019-10-29T21:28:27Z ["General Veterinary", "General Medicine"] 0 0 ["0042-4900", "2042-7670"] Veterinary Record <jats:sec><jats:title>Background</jats:title><jats:p>The aims of this study were to determine if extrahepatic portosystemic shunt (EHPSS) postoperative closure could be predicted based on preoperative blood analyses and to determine the accuracy of blood variables to evaluate persistence of portosystemic shunting postoperatively (multiple acquired portosystemic shunts (MAPSS) or persistent EHPSS).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Retrospectively, 62 dogs treated surgically for congenital EHPSS that underwent postoperative trans-splenic portal scintigraphy or CT angiography three to six months postoperatively were included.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>None of the studied preoperative blood variables could unambiguously predict surgical outcome. Elevated postoperative fasting venous ammonia (FA) concentration always indicated surgical failure (persistent shunting or MAPSS), but normal FA did not provide any information on the postoperative shunting status. Paired serum bile acids (SBA) were not reliable enough to confirm or exclude postoperative shunting. In the presence of low normal postoperative FA levels, elevated preprandial SBA was more likely in dogs with persistent shunting (sensitivity of 0.79, specificity of 0.83), whereas postprandial SBA below reference limit was more often observed in case of surgical success (sensitivity of 0.93, specificity of 0.67).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Blood variables, and more specifically the combination of FA and SBA, are not a valuable alternative to advanced medical imaging to reliably assess the surgical outcome after EHPSS surgery.</jats:p></jats:sec> 9 ["http://orcid.org/0000-0002-2426-9296"] ["Nicolas Vallarino", "Steven Pil", "Nausikaa Devriendt", "Matan Or", "Eva Vandermeulen", "Gon\u00e7alo Serrano", "Dominique Paepe", "Tim Bosmans", "Hilde de Rooster"] [""] [""] [""]

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CREATE TABLE [article] (
   [title] TEXT,
   [DOI] TEXT,
   [URL] TEXT,
   [created] TEXT,
   [subject] TEXT,
   [references-count] TEXT,
   [is-referenced-by-count] TEXT,
   [ISSN] TEXT,
   [container-title] TEXT,
   [abstract] TEXT,
   [author_number] TEXT,
   [orcids] TEXT,
   [names] TEXT,
   [award_numbers] TEXT,
   [funder_names] TEXT,
   [funder_dois] TEXT
);