2 rows where ISSN contains "1468-2052"
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|69||69||["Cell therapy for the preterm infant: promise and practicalities"]||10.1136/archdischild-2019-317896||http://dx.doi.org/10.1136/archdischild-2019-317896||2020-04-06T21:15:32Z||["Obstetrics and Gynaecology", "Pediatrics, Perinatology, and Child Health", "General Medicine"]||0||0||["1359-2998", "1468-2052"]||Archives of Disease in Childhood - Fetal and Neonatal Edition||<jats:p>Recent decades have seen the rapid progress of neonatal intensive care, and the survival rates of the most preterm infants are improving. This improvement is associated with changing patterns of morbidity and new phenotypes of bronchopulmonary dysplasia and preterm brain injury are recognised. Inflammation and immaturity are known contributors to their pathogenesis. However, a new phenomenon, the exhaustion of progenitor cells is emerging as an important factor. Current therapeutic approaches do not adequately address these new mechanisms of injury. Cell therapy, that is the use of stem and stem-like cells, with its potential to both repair and prevent injury, offers a new approach to these challenging conditions. This review will examine the rationale for cell therapy in the extremely preterm infant, the preclinical and early clinical evidence to support its use in bronchopulmonary dysplasia and preterm brain injury. Finally, it will address the challenges in translating cell therapy from the laboratory to early clinical trials.</jats:p>||5||["http://orcid.org/0000-0001-6742-7314"]||["Elizabeth K Baker", "Susan E Jacobs", "Rebecca Lim", "Euan M Wallace", "Peter G Davis"]||["Research Training Program Scholarship"]||["University of Melbourne", "National Health and Medical Research Council"]||["10.13039/501100001782", "10.13039/501100000925"]|
|72||72||["Diffuse excessive high signal intensity on term equivalent MRI does not predict disability: a systematic review and meta-analysis"]||10.1136/archdischild-2019-318207||http://dx.doi.org/10.1136/archdischild-2019-318207||2020-05-25T21:17:07Z||["Obstetrics and Gynaecology", "Pediatrics, Perinatology, and Child Health", "General Medicine"]||39||0||["1359-2998", "1468-2052"]||Archives of Disease in Childhood - Fetal and Neonatal Edition||<jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate whether diffuse excessive high signal intensity (DEHSI) on term equivalent age MRI (TEA-MRI) predicts disability in preterm infants.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>This is a systematic review and meta-analysis. Medline, EMBASE, Cochrane Library, EMCARE, Google Scholar and MedNar databases were searched in July 2019. Studies comparing developmental outcomes of isolated DEHSI on TEA-MRI versus normal TEA-MRI were included. Two reviewers independently extracted data and assessed the risk of bias. Meta-analysis was undertaken where data were available in a format suitable for pooling.</jats:p></jats:sec><jats:sec><jats:title>Main outcome measures</jats:title><jats:p>Neurodevelopmental outcomes ≥1 year of corrected age based on validated tools.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 15 studies (n=1832) were included, of which data from 9 studies were available for meta-analysis. The pooled estimate (n=7) for sensitivity of DEHSI in predicting cognitive/mental disability was 0.58 (95% CI 0.34 to 0.79) and for specificity was 0.46 (95% CI 0.20 to 0.74). The summary area under the receiver operating characteristics (ROC) curve was low at 0.54 (CI 0.50 to 0.58). A pooled diagnostic OR (DOR) of 1 indicated that DEHSI does not discriminate preterm infants with and without mental disability. The pooled estimate (n=8) for sensitivity of DEHSI in predicting cerebral palsy (CP) was 0.57 (95% CI 0.37 to 0.75) and for specificity was 0.41 (95% CI 0.24 to 0.62). The summary area under the ROC curve was low at 0.51 (CI 0.46 to 0.55). A pooled DOR of 1 indicated that DEHSI does not discriminate between preterm infants with and without CP.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>DEHSI on TEA-MRI did not predict future development of cognitive/mental disabilities or CP.</jats:p></jats:sec><jats:sec><jats:title>PROSPERO registration number</jats:title><jats:p>CRD4…||4||||["Chandra Prakash Rath", "Saumil Desai", "Shripada C Rao", "Sanjay Patole"]||[""]||[""]||[""]|
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