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Link rowid ▼ title DOI URL created subject references-count is-referenced-by-count ISSN container-title abstract author_number orcids names award_numbers funder_names funder_dois
19 ["Clinical significance of the circle of Willis in intracranial atherosclerotic stenosis"] 10.1136/neurintsurg-2014-011439 http://dx.doi.org/10.1136/neurintsurg-2014-011439 2014-12-10T04:09:30Z [] 19 6 ["1759-8478", "1759-8486"] Journal of NeuroInterventional Surgery <jats:sec><jats:title>Introduction</jats:title><jats:p>The effectiveness of a scoring system based on the circle of Willis for evaluations of collateral circulation was studied in patients with intracranial atherosclerotic stenosis.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Eighty-three patients who underwent medical or endovascular treatment for symptomatic and severe intracranial atherosclerotic stenosis were enrolled in the study. Clinical profiles, status of the circle of Willis (poor and good integrity group), and clinical outcomes were analyzed. Primary endpoints were: (1) symptomatic ischemic or hemorrhagic stroke within 30 days; and (2) recurrent transient ischemic attack or ischemic stroke beyond 30 days.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The estimated rates of the primary endpoint at 1 and 2 years after treatment were 8.5% and 11.4% in the medical group and 7.0% and 9.7% in the endovascular group, respectively. A primary endpoint event after medical treatment was only identified in patients with poor integrity of the circle of Willis (p=0.059). In patients with poor integrity of the circle of Willis, previous antiplatelet medication before initial presentation (p=0.026) and hypertension (p=0.006) were more prevalent. During the follow-up period, complete arterial occlusion was identified in 9 patients. The circle of Willis score of the patients with complete arterial occlusion was 1.33±1.52 in the fatal stroke group (n=3) and 3.20±1.64 in the asymptomatic group (n=6, p=0.099).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>If patients have poor integrity of the circle of Willis, the risk of recurrent stroke may be increased. Such patients appear to be good candidates for endovascular treatment.</jats:p></jats:sec> 6 [] ["Kang Min Kim", "Hyun-Seung Kang", "Woong Jae Lee", "Young Dae Cho", "Jeong Eun Kim", "Moon Hee Han"] [""] [""] [""]
20 ["Google search histories of patients presenting to an emergency department: an observational study"] 10.1136/bmjopen-2018-024791 http://dx.doi.org/10.1136/bmjopen-2018-024791 2019-02-20T19:00:11Z ["General Medicine"] 0 6 ["2044-6055", "2044-6055"] BMJ Open <jats:sec><jats:title>Objective</jats:title><jats:p>To test patients’ willingness to share and link their prior Google search histories with data from their electronic medical record (EMR), and to explore associations between search histories and clinical conditions.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Cross-sectional study of emergency department (ED) patients from 2016 to 2017.</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>Academic medical centre ED.</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>A total of 703 patients were approached; 334 of a volunteer sample of 411 (81%) reported having a Google account; 165 of those (49%) consented to share their Google search histories and EMR data; 119 (72%) were able to do so. 16 (13%) of those 119 patients had no data and were not included in the final count. Patients under the age of 18 or with a triage level of 1 were considered ineligible and were not approached.</jats:p></jats:sec><jats:sec><jats:title>Main outcome measures</jats:title><jats:p>Health relatedness of searches in the remote past and within 7 days of the ED visit, and associations between patients’ clinical and demographic characteristics and their internet search volume and search content.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The 103 participants yielded 591 421 unique search queries; 37 469 (6%) were health related. In the 7 days prior to an ED visit, the percentage of health-related searches was 15%. During that time, 56% of patients searched for symptoms, 53% for information about a hospital and 23% about the treatment or management of a disease. 53% of participants who used Google in the week leading up to their ED visit searched for content directly related to their chief complaint.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Patients were willing to allow researchers simultaneous access to their Google search histories and their EMR data. The change in vo… 6 [] ["Jeremy M Asch", "David A Asch", "Elissa V Klinger", "Justine Marks", "Norah Sadek", "Raina M Merchant"] [] ["Robert Wood Johnson Foundation"] ["10.13039/100000867"]
21 ["Association between frontal plane knee control and lower extremity injuries: a prospective study on young team sport athletes"] 10.1136/bmjsem-2017-000311 http://dx.doi.org/10.1136/bmjsem-2017-000311 2018-01-14T01:10:19Z [] 47 6 ["2055-7647"] BMJ Open Sport & Exercise Medicine <jats:sec><jats:title>Background/aim</jats:title><jats:p>Poor frontal plane knee control can manifest as increased dynamic knee valgus during athletic tasks. The purpose of this study was to investigate the association between frontal plane knee control and the risk of acute lower extremity injuries. In addition, we wanted to study if the single-leg squat (SLS) test can be used as a screening tool to identify athletes with an increased injury risk.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A total of 306 basketball and floorball players participated in the baseline SLS test and a 12-month injury registration follow-up. Acute lower extremity time-loss injuries were registered. Frontal plane knee projection angles (FPKPA) during the SLS were calculated using a two-dimensional video analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Athletes displaying a high FPKPA were 2.7 times more likely to sustain a lower extremity injury (adjusted OR 2.67, 95% CI 1.23 to 5.83) and 2.4 times more likely to sustain an ankle injury (OR 2.37, 95% CI 1.13 to 4.98). There was no statistically significant association between FPKPA and knee injury (OR 1.49, 95% CI 0.56 to 3.98). The receiver operating characteristic curve analyses indicated poor combined sensitivity and specificity when FPKPA was used as a screening test for lower extremity injuries (area under the curve of 0.59) and ankle injuries (area under the curve of 0.58).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Athletes displaying a large FPKPA in the SLS test had an elevated risk of acute lower extremity and ankle injuries. However, the SLS test is not sensitive and specific enough to be used as a screening tool for future injury risk.</jats:p></jats:sec> 10 ["http://orcid.org/0000-0003-3056-8169"] ["Anu M R\u00e4is\u00e4nen", "Kati Pasanen", "Tron Krosshaug", "Tommi Vasankari", "Pekka Kannus", "Ari Heinonen", "Urho M Kujala", "Janne Avela", "Jarmo Perttunen", "Jari Parkkari"] [] ["The Foundation of Sports Institute", "the Competitive State Research Financing of The Expert Responsibility Area of Tampere University Hospital", "The Finnish Ministry of Education and Culture"] [[""], [""], [""]]
22 ["EGFR gene copy number as a predictive/biomarker for patients with non-small-cell lung cancer receiving tyrosine kinase inhibitor treatment: a systematic review and meta-analysis"] 10.1136/jim-2016-000252 http://dx.doi.org/10.1136/jim-2016-000252 2016-09-24T02:48:22Z [] 41 6 ["1081-5589", "1708-8267"] Journal of Investigative Medicine <jats:p>Epidermal growth factor receptor (<jats:italic>EGFR</jats:italic>) gene copy number has been proposed as a candidate biomarker for predicting treatment response to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in patients with advanced non-small-cell lung cancer (NSCLC). MEDLINE, PubMed, Cochrane, and Google Scholar databases were searched until October 21, 2015 using the following search terms: lung neoplasms/lung cancer/non-small cell lung cancer/NSCLC, EGFR, gene amplification, copy number, erlotinib, gefitinib, tyrosine-kinase inhibitor/TKI, predictor. 17 studies were included in the analysis with a total of 2047 patients. The overall analysis found that increased <jats:italic>EGFR</jats:italic> gene copy number was associated with higher overall response rate (ORR), overall survival (OS) and progression-free survival (PFS; p values ≤0.008) compared with patients without a high <jats:italic>EGFR</jats:italic> gene copy number. Subgroup analysis found that in a population of patients who were primarily Caucasian, a higher <jats:italic>EGFR</jats:italic> gene copy number was also associated with increased ORR, OS, and PFS (p values ≤0.018). The results were similar in a population of Asian patients, except that a higher <jats:italic>EGFR</jats:italic> gene copy number was not associated with improved OS (p=0.248). Sensitivity analysis indicated that no one study overly influenced the results and that the findings are robust. The result of the analysis found that <jats:italic>EGFR</jats:italic> gene copy number was associated with increased OS and PFS, supporting the idea that <jats:italic>EGFR</jats:italic> gene copy number is a biomarker for response to EGFR-TKI therapy in patients with advanced NSCLC.</jats:p> 4 [] ["Xin Zhang", "Yiwen Zhang", "Hailing Tang", "Jianxing He"] [""] [""] [""]

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   [URL] TEXT,
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