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Link | rowid | title | DOI | URL | created | subject | references-count | is-referenced-by-count | ISSN | container-title | abstract | author_number | orcids ▼ | names | award_numbers | funder_names | funder_dois |
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71 | 71 | ["Phase III randomized pilot study comparing interferon \u03b1- 2b in combination with radiation therapy versus radiation therapy alone in patients with stage III-B carcinoma of the cervix"] | 10.1136/ijgc-00009577-200303000-00011 | http://dx.doi.org/10.1136/ijgc-00009577-200303000-00011 | 2019-03-06T14:50:37Z | ["Obstetrics and Gynaecology", "Oncology"] | 0 | 0 | ["1048-891X", "1525-1438"] | International Journal of Gynecologic Cancer | <jats:p>This randomized pilot study was designed to determine whether the addition of interferon α-2b to standard radiation therapy offered an advantage in loco-regional control and survival over radiation therapy alone in a homogeneous group of patients with stage IIIB carcinoma of the cervix. Thirty-six patients were treated with a combination of interferon α-2b plus radiation therapy, and 38 patients were treated with radiation therapy alone. Patients with evidence of ureteral obstruction were excluded from the study. Evaluation of loco-regional response was determined by pelvic examination, cervical cytology, biopsies and CT scans when indicated. Survival time was measured from initiation of treatment to date of death or last follow-up. Patient characteristics were comparable between both study arms. The objective complete response rate was 67% in the combined therapy group and 55% in the radiation alone group (<jats:italic>P</jats:italic> = 0.454). With a median follow-up of 17 months for all patients and 31 months for live patients, 50% of the combined group survived vs. 39.5% of the radiation alone group (<jats:italic>P</jats:italic> = 0.424). We conclude that the addition of interferon α-2b to standard radiation therapy did not significantly improve loco-regional response or survival, although such a trend was noted. We encourage the design of a larger randomized study with sufficient power to detect meaningful differences to prove whether the tendency observed in the present investigation holds any promise to improve the outcome of these patients.</jats:p> | 14 | [] | ["R. Yazigi", "G. Aliste", "R. Torres", "A. M. Ciudad", "M. Cuevas", "J. Garrido", "S. Prado", "A. Sol\u00e1", "R. Castillo", "B. Cerda", "M. A. Cumsille", "M. Gonz\u00e1lez", "C. Navarro", "J. M. Reyes"] | [""] | [""] | [""] |
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CREATE TABLE [article] ( [title] TEXT, [DOI] TEXT, [URL] TEXT, [created] TEXT, [subject] TEXT, [references-count] TEXT, [is-referenced-by-count] TEXT, [ISSN] TEXT, [container-title] TEXT, [abstract] TEXT, [author_number] TEXT, [orcids] TEXT, [names] TEXT, [award_numbers] TEXT, [funder_names] TEXT, [funder_dois] TEXT );